Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 6/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26097655 | 0.79 | APLNR (0.39) | APLNRNAAAAURKADHFRLMNA | |
| SCHEMBL19550276 | 0.77 | APLNR (0.47) | RECQLAPLNRLMNACA2CA1 | |
| SCHEMBL18247004 | 0.77 | APLNR (0.67) | RECQLAPLNRCA2CA1CA9 | |
| SCHEMBL18247184 | 0.77 | APLNR (0.43) | RECQLAPLNRCA2CA1CA9 | |
| SCHEMBL1154520 | 0.76 | CA1 (0.44) | AURKADHFRLMNATSHRCA2 | |
| SCHEMBL4184428 | 0.75 | HRH1 (0.57) | LMNACA2CA1PRMT1 | |
| Potassium SCHEMBL4063307 | 0.74 | HRH1 (0.55) | LMNACA2CA1PRMT1 | |
| SCHEMBL4063300 | 0.74 | HRH1 (0.55) | LMNACA2CA1PRMT1 | |
| SCHEMBL29170700 | 0.70 | NAAA (0.42) | APLNRNAAALMNA | |
| Ethanesulfonic Acid Amide SCHEMBL16569730 | 0.70 | COMT (0.38) | AURKADHFRLMNATSHRCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049494-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008310-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | claimed |