SCHEMBL4246083

SCHEMBL4246083

CC1OC(C)(C(=O)O)OCC1Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1

nearest known ligand 0.51

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 10/20 0.51
PPARG P37231 10/20 0.51
PPARD Q03181 1/20 0.42
CACNA1H O95180 2/20 0.37
CACNA1B Q00975 2/20 0.37
SMPD1 P17405 1/20 0.37
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
LTA4H P09960 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4243674 0.88 PPARA (0.55) PPARAPPARGPPARDCACNA1HCACNA1B
SCHEMBL4252339 0.84 PPARG (0.41) PPARAPPARGKDM4EMEN1KMT2A
SCHEMBL4246492 0.81 PPARA (0.51) PPARAPPARGPPARDCACNA1HCACNA1B
SCHEMBL4246496 0.81 PPARA (0.51) PPARAPPARGPPARDCACNA1HCACNA1B
SCHEMBL4246081 0.81 PPARA (0.51) PPARAPPARGPPARDCACNA1HCACNA1B
SCHEMBL5450514 0.80 SIGMAR1 (0.37) PPARAPPARGSMPD1MEN1KMT2A
SCHEMBL4251665 0.80 PPARG (0.51) PPARAPPARGKDM4EMEN1KMT2A
SCHEMBL4252047 0.76 PPARG (0.54) PPARAPPARGKDM4EMEN1KMT2A
SCHEMBL4250655 0.76 PPARG (0.54) PPARAPPARGKDM4EMEN1KMT2A
SCHEMBL4250656 0.76 PPARG (0.54) PPARAPPARGKDM4EMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090012069-A1 Novel Antidiabetic Compounds CADILA HEALTHCARE LIMITED (IN) 2009-01-08 US claimed
EP-1781633-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2007-05-09 EP claimed
WO-2006018855-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2006-02-23 WO claimed
US-20090012069-A1 Novel Antidiabetic Compounds CADILA HEALTHCARE LIMITED (IN) 2009-01-08 US disclosed
EP-1781633-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2007-05-09 EP disclosed
WO-2006018855-A1 NOVEL ANTIDIABETIC COMPOUNDS CADILA HEALTHCARE LIMITED (IN) 2006-02-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012069-A1 Novel Antidiabetic Compounds GPR119, SLC5A1, SLC5A2 PPARA 145/4885PPARG 76/4885PPARD 54/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.