Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | CCR4 | P51679 | 1/20 | 0.31 |
| ▸ | CD4 | P01730 | 1/20 | 0.31 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564514 | 0.82 | F10 (0.60) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL6078874 | 0.82 | F10 (0.71) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL4522849 | 0.81 | F10 (0.58) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL4452402 | 0.80 | CYP2D6 (0.33) | ALDH1A1TSHRMAPK1HSD11B1USP2 | |
| SCHEMBL7261609 | 0.80 | F10 (0.57) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL4529442 | 0.76 | KDM4E (0.34) | ALDH1A1KDM4ETRPV4TSHRUSP2 | |
| SCHEMBL6079458 | 0.71 | F10 (0.44) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL6079274 | 0.69 | F10 (0.47) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL4534417 | 0.69 | F10 (0.45) | F10ALDH1A1KDM4ETRPV4TSHR | |
| SCHEMBL6079421 | 0.69 | F10 (0.73) | F10TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090170844-A1 | Spiro Tetracyclic Compound | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-2020411-A1 | SPIRO TETRACYCLIC COMPOUND | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-02-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170844-A1 | Spiro Tetracyclic Compound | KCNH1, TFPI, KCNN2 | F10 127/4885ALDH1A1 2243/4885KDM4E 2878/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.