Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 11/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4246121 | 0.80 | F10 (0.51) | CYP2D6CYP3A4ALDH1A1TSHRUSP2 | |
| SCHEMBL4237209 | 0.79 | CYP2D6 (0.41) | CYP2D6OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4454901 | 0.79 | CYP2D6 (0.42) | CYP2D6OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4522977 | 0.77 | CYP2D6 (0.47) | CYP2D6OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4519652 | 0.75 | CYP2D6 (0.41) | CYP2D6OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL4454104 | 0.70 | POLB (0.44) | ALDH1A1MAPK1MEN1HTTKMT2A | |
| SCHEMBL6079416 | 0.69 | CYP2D6 (0.45) | CYP2D6OPRD1OPRK1CYP3A4CHRM2 | |
| SCHEMBL4449570 | 0.67 | POLB (0.43) | ALDH1A1L3MBTL1MEN1HTTKMT2A | |
| SCHEMBL12610592 | 0.66 | DRD4 (0.48) | CYP2D6CYP3A4 | |
| SCHEMBL4526398 | 0.65 | CYP2D6 (0.48) | CYP2D6CYP3A4CHRM2ALDH1A1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2020411-A1 | SPIRO TETRACYCLIC COMPOUND | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-02-04 | — | — | EP | disclosed |