Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LSS | P48449 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28269086 | 0.82 | LSS (0.66) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL8100035 | 0.81 | SIGMAR1 (0.50) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL4700697 | 0.81 | SIGMAR1 (0.50) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL1586376 | 0.81 | SIGMAR1 (0.50) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL4246188 | 0.81 | ACHE (0.68) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL23304299 | 0.81 | SIGMAR1 (0.54) | SIGMAR1TRPV6KDM4EMEN1ALDH1A1 | |
| SCHEMBL1232375 | 0.81 | ACHE (0.67) | SIGMAR1ALDH1A1CXCR4 | |
| Hydrochloric Acid SCHEMBL6039717 | 0.80 | SIGMAR1 (0.49) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| SCHEMBL13128763 | 0.80 | SIGMAR1 (0.49) | LSSSIGMAR1TRPV6KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL2674716 | 0.80 | SIGMAR1 (0.49) | LSSSIGMAR1TRPV6KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LIMITED (GB) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247504-A1 | Indazole Derivatives for Treatment of Alzheimer's Disease | MAPT, PSEN2, PSEN1 | LSS 977/4885SIGMAR1 3130/4885TRPV6 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.