SCHEMBL4246366

SCHEMBL4246366

Cc1c(C(=O)S)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.76

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 14/20 0.76
CNR1 P21554 6/20 0.74
PPARA Q07869 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL924033 0.90 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL6173947 0.90 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL276817 0.90 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL30571219 0.90 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL922969 0.89 CNR2 (0.77) CNR2CNR1PPARA
SCHEMBL29388169 0.89 CNR2 (0.77) CNR2CNR1PPARA
Hydrochloric Acid SCHEMBL3002214 0.89 CNR2 (0.74) CNR2CNR1PPARA
SCHEMBL26053905 0.88 CNR2 (0.76) CNR2CNR1
SCHEMBL2734336 0.86 CNR2 (0.83) CNR2CNR1PPARA
SCHEMBL908310 0.86 CNR2 (0.75) CNR2CNR1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090156616-A1 THERAPEUTIC AGENTS ASTRAZENECA AB (SE) 2009-06-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156616-A1 THERAPEUTIC AGENTS NLN, BDNF, GAP43 CNR2 209/4885CNR1 173/4885PPARA 504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.