SCHEMBL922969

SCHEMBL922969

Cc1c(C(N)=O)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Cl)cc1

nearest known ligand 0.77

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 14/20 0.77
CNR1 P21554 6/20 0.77
PPARA Q07869 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388169 1.00 CNR2 (0.77) CNR2CNR1PPARA
SCHEMBL12907719 0.95 CNR2 (0.70) CNR2CNR1PPARA
SCHEMBL17565777 0.94 CNR2 (0.69) CNR2CNR1
Piperidine SCHEMBL6094702 0.90 CNR2 (0.64) CNR2CNR1
SCHEMBL6173947 0.89 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL4246366 0.89 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL276817 0.89 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL30571219 0.89 CNR2 (0.76) CNR2CNR1PPARA
SCHEMBL924033 0.89 CNR2 (0.76) CNR2CNR1PPARA
Hydrochloric Acid SCHEMBL3002214 0.88 CNR2 (0.74) CNR2CNR1PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7763607-B2 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2010-07-27 US claimed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US claimed
US-20230172874-A1 USE OF CANNABIDIOL FOR THE TREATMENT OF INSOMNIA ASSOCIATED TO PAIN GOBBI GABRIELLA (CA) 2023-06-08 US disclosed
WO-2023089612-A1 PERIPHERAL CB1 RECEPTOR ANTAGONISTS FOR TREATMENT OF LOWER URINARY TRACT SYMPTOMS (LUTS) YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2023-05-25 WO disclosed
US-11655238-B2 MMPL3 inhibitors, compositions and uses thereof SHANGHAITECH UNIVERSITY (CN) 2023-05-23 US disclosed
US-11655238-B2 MMPL3 inhibitors, compositions and uses thereof SHANGHAITECH UNIVERSITY (CN) 2023-05-23 US disclosed
US-20220119365-A1 CB1R RECEPTOR BLOCKERS WITH ACYCLIC BACKBONES YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2022-04-21 US disclosed
US-20220017492-A1 MMPL3 INHIBITORS, COMPOSITIONS AND USES THEREOF SHANGHAITECH UNIVERSITY (CN) 2022-01-20 US disclosed
US-20190343822-A1 TREATMENT FOR GLAUCOMA INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION 2019-11-14 US disclosed
US-9662320-B2 Antagonists of the cannabinoid receptor CB1 for use in the treatment of diseases associated with neuronal dendritic abnormalities UNIVERSITAT POMPEU FABRA (ES) 2017-05-30 US disclosed
US-20080081812-A1 Heteroaryl-Pyrazole Derivatives as Cannabinoid CB1 Receptor Antagonists GREEN CROSS CORPORATION (KR) 2008-04-03 US disclosed
US-20080039510-A1 (1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFI-AVENTIS (FR) 2008-02-14 US disclosed
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators SOLVAY PHARMACEUTICALS GMBH (DE) 2007-11-01 US disclosed
WO-2007035945-A1 TETRAHYDRO-CYCLOPENTYL PYRAZOLE CANNABINOID MODULATORS JANSSEN PHARMACEUTICA, N.V. (BE) 2007-03-29 WO disclosed
WO-2006087732-A1 AN AMORPHOUS AND THREE CRYSTALLINE FORMS OF RIMONABANT HYDROCHLORIDE CADILA HEALTHCARE LIMITED (IN) 2006-08-24 WO disclosed
EP-1556373-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF Pfizer Products Inc. (US) 2005-07-27 EP disclosed
WO-2004035566-A1 CANNABINOID RECEPTOR LIGANDS AND USES THEREOF PFIZER PRODUCTS INC. (US) 2004-04-29 WO disclosed
US-20040077650-A1 Cannabinoid receptor ligands and uses thereof PFIZER INC. 2004-04-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040077650-A1 Cannabinoid receptor ligands and uses thereof CNR1, CNR2, GPR18 CNR2 2/4885CNR1 1/4885PPARA 201/4885
US-11655238-B2 MMPL3 inhibitors, compositions and uses thereof TIMP3, AFG3L2, MMP3 CNR2 4645/4885CNR1 4650/4885PPARA 3243/4885
US-20220017492-A1 MMPL3 INHIBITORS, COMPOSITIONS AND USES THEREOF TIMP3, AFG3L2, MMP3 CNR2 4645/4885CNR1 4650/4885PPARA 3243/4885
US-20070254863-A1 Use of CBx cannabinoid receptor modulators as potassium channel modulators CNR2, CNR1, KCNN1 CNR2 1/4885CNR1 2/4885PPARA 621/4885
US-20080039510-A1 (1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS DHFR, DPYD, THPO CNR2 933/4885CNR1 767/4885PPARA 1910/4885
US-20080081812-A1 Heteroaryl-Pyrazole Derivatives as Cannabinoid CB1 Receptor Antagonists CNR2, CNR1, GPR119 CNR2 1/4885CNR1 2/4885PPARA 27/4885
US-20070254862-A1 Pharmaceutical compositions comprising CBx cannabinoid receptor modulators and potassium channel modulators CNR1, CNR2, KCNJ11 CNR2 2/4885CNR1 1/4885PPARA 703/4885
US-20220119365-A1 CB1R RECEPTOR BLOCKERS WITH ACYCLIC BACKBONES CNR1, CNR2, HCRTR1 CNR2 2/4885CNR1 1/4885PPARA 800/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.