Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 9/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247238 | 1.00 | GNRHR (0.40) | GNRHRKIF11BRD4DYRK1ASIGMAR1 | |
| SCHEMBL4248792 | 0.91 | GNRHR (0.38) | GNRHRKIF11BRD4DYRK1ASIGMAR1 | |
| SCHEMBL4248789 | 0.91 | GNRHR (0.38) | GNRHRKIF11BRD4DYRK1ASIGMAR1 | |
| SCHEMBL4252319 | 0.90 | BRD4 (0.39) | GNRHRKIF11BRD4DYRK1ANPSR1 | |
| SCHEMBL4252323 | 0.90 | BRD4 (0.39) | GNRHRKIF11BRD4DYRK1ANPSR1 | |
| SCHEMBL4250470 | 0.86 | GNRHR (0.39) | GNRHRKIF11BRD4DYRK1ANPSR1 | |
| SCHEMBL4250472 | 0.86 | GNRHR (0.39) | GNRHRKIF11BRD4DYRK1ANPSR1 | |
| SCHEMBL4253648 | 0.85 | BRD4 (0.39) | GNRHRKIF11BRD4SIGMAR1CCNC | |
| SCHEMBL4253643 | 0.85 | BRD4 (0.39) | GNRHRKIF11BRD4SIGMAR1CCNC | |
| SCHEMBL4250123 | 0.85 | KIF11 (0.39) | GNRHRKIF11BRD4DYRK1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |