Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5929136 | 0.77 | MAPT (0.50) | LMNANPC1TSHRADORA2AALDH1A1 | |
| SCHEMBL4543879 | 0.77 | LMNA (0.41) | LMNANPC1TSHRADORA2AALDH1A1 | |
| SCHEMBL860591 | 0.72 | — | — | |
| SCHEMBL15722750 | 0.72 | MAPT (0.49) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL13227914 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL15722731 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL15722788 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL15722749 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL15722729 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A | |
| SCHEMBL15722801 | 0.70 | MAPT (0.47) | LMNANPC1ADORA2AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010535-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120098-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |