Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8199036 | 0.95 | GRIN2B (0.41) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL2981422 | 0.82 | JAK3 (0.48) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL20399337 | 0.81 | CTSK (0.39) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL21530334 | 0.81 | CTSK (0.39) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL21530335 | 0.81 | CTSK (0.39) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL26126544 | 0.80 | JAK3 (0.49) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL29584537 | 0.80 | JAK3 (0.47) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL28334752 | 0.80 | CTSK (0.38) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL24999579 | 0.79 | CTSK (0.37) | JAK3CTSKGRIN2BGRIN2CHPGD | |
| SCHEMBL28832612 | 0.79 | GRIN2B (0.40) | JAK3CTSKGRIN2BGRIN2CHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-A1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007122103-A1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-11-01 | — | — | WO | disclosed |