SCHEMBL4247906

SCHEMBL4247906

CCOC(=O)c1cc(=O)c2c([N+](=O)[O-])cccc2o1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AKR1B1 P15121 1/20 0.51
MAPK1 P28482 1/20 0.51
MAOB P27338 2/20 0.50
LMNA P02545 2/20 0.49
SLC2A1 P11166 1/20 0.44
HIF1A Q16665 1/20 0.44
GPR35 Q9HC97 1/20 0.43
ATM Q13315 1/20 0.43
CACNA1C Q13936 1/20 0.43
MAPT P10636 4/20 0.43
ALDH1A1 P00352 3/20 0.43
KDM4E B2RXH2 1/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
RAB9A P51151 2/20 0.42
NPC1 O15118 1/20 0.42
GAA P10253 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4252382 0.91 MAOB (0.61) AKR1B1MAPK1MAOBLMNAGPR35
SCHEMBL4252108 0.89 MAOB (0.53) AKR1B1MAPK1MAOBLMNAGPR35
SCHEMBL4254519 0.88 LMNA (0.47) AKR1B1MAPK1MAOBLMNAHIF1A
SCHEMBL4249348 0.88 MAOB (0.52) MAPK1MAOBLMNAGPR35CACNA1C
SCHEMBL4251481 0.87 ESR1 (0.51) MAPK1MAOBLMNAGPR35CACNA1C
SCHEMBL4250020 0.86 LMNA (0.65) MAPK1MAOBLMNAHIF1AGPR35
SCHEMBL4246467 0.84 LMNA (0.50) AKR1B1MAPK1MAOBLMNAHIF1A
SCHEMBL4251498 0.83 LMNA (0.49) MAPK1MAOBLMNAHIF1AGPR35
SCHEMBL4249992 0.82 GPR35 (0.67) AKR1B1MAOBLMNASLC2A1HIF1A
SCHEMBL4251548 0.81 AKR1B1 (0.56) AKR1B1MAPK1MAOBSLC2A1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed
US-4419352-A ANTIALLERGENS; ANTI SECRETORY AGENTS; MUCUS FISONS LIMITED (GB) 1983-12-06 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL AKR1B1 237/4885MAPK1 1662/4885MAOB 476/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL AKR1B1 237/4885MAPK1 1662/4885MAOB 476/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.