⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28694931 | 0.94 | GRM5 (0.36) | — | |
| SCHEMBL29429073 | 0.82 | ALDH1A1 (0.48) | — | |
| SCHEMBL3765744 | 0.79 | — | — | |
| SCHEMBL535712 | 0.77 | — | — | |
| SCHEMBL7466739 | 0.77 | — | — | |
| SCHEMBL5700069 | 0.74 | — | — | |
| SCHEMBL981103 | 0.74 | GRM5 (0.50) | — | |
| SCHEMBL15085757 | 0.74 | NOS3 (0.39) | — | |
| SCHEMBL16742535 | 0.73 | — | — | |
| SCHEMBL1173370 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291523-B2 | LXR modulators with bicyclic core moiety | ORSOBIO, INC. (US) | 2025-05-06 | — | — | US | disclosed |
| US-20240317726-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO, INC. | 2024-09-26 | — | — | US | disclosed |
| US-11970484-B2 | LXR modulators with bicyclic core moiety | ORSOBIO, INC. (US) | 2024-04-30 | — | — | US | disclosed |
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
| US-20230357214-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX PHARMACEUTICALS AKTIENGESELLSCHAFT (DE) | 2023-11-09 | — | — | US | disclosed |
| EP-3814331-B9 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-08-09 | — | — | EP | disclosed |
| EP-3814331-B1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-06-14 | — | — | EP | disclosed |
| EP-3814331-B1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | ORSOBIO INC (US) | 2023-06-14 | — | — | EP | disclosed |
| US-11618747-B2 | LXR modulators with bicyclic core moiety | ORSOBIO, INC. (US) | 2023-04-04 | — | — | US | disclosed |
| US-20210147398-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | PHENEX-FXR GMBH (DE) | 2021-05-20 | — | — | US | disclosed |
| EP-3814331-A1 | NOVEL LXR MODULATORS WITH BICYCLIC CORE MOIETY | Phenex-FXR GmbH (DE) | 2021-05-05 | — | — | EP | disclosed |
| CN-112689630-A | Novel LXR modulators with bicyclic core moieties | 菲尼克斯-FXR股份有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-106458920-B | Alkynyl indazole derivative and application thereof | 千寿制药株式会社 | 2019-02-15 | — | — | CN | disclosed |
| CN-106458920-A | Alkynyl indazole derivative and use thereof | 千寿制药株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-102781923-A | 5-alkynyl-pyrimidines | BOEHRINGER INGELHEIM INT | 2012-11-14 | — | — | CN | disclosed |
| CN-102112450-A | 5-alkynyl-pyrimidines | BOEHRINGER INGELHEIM INT | 2011-06-29 | — | — | CN | disclosed |
| EP-2023933-A2 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMACEUTICALS, INC. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007133560-A9 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMA INC (US) | 2008-11-13 | — | — | WO | disclosed |
| WO-2007133560-A2 | ACETYLENIC HETEROARYL COMPOUNDS | ARIAD PHARMACEUTICALS, INC. (US) | 2007-11-22 | — | — | WO | disclosed |