Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT3B | Q9UBC3 | 4/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.34 |
| ▸ | HNMT | P50135 | 2/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 3/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.33 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.33 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.33 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.33 |
| ▸ | INMT | O95050 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | NNMT | P40261 | 1/20 | 0.33 |
| ▸ | WDR5 | P61964 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.33 |
| ▸ | RBBP5 | Q15291 | 1/20 | 0.33 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4247653 | 0.78 | HNMT (0.36) | DNMT3BDNMT1HNMTDOT1LCARM1 | |
| SCHEMBL4159564 | 0.67 | MTAP (0.71) | — | |
| SCHEMBL15318133 | 0.67 | PNP (0.64) | — | |
| SCHEMBL14174651 | 0.57 | DNMT3B (0.48) | DNMT3BDNMT1HNMTDOT1LCARM1 | |
| SCHEMBL27791649 | 0.57 | BHMT (0.76) | — | |
| SCHEMBL1031684 | 0.57 | BHMT (0.76) | — | |
| SCHEMBL1031686 | 0.57 | BHMT (0.76) | — | |
| SCHEMBL21851894 | 0.57 | BHMT (0.76) | — | |
| SCHEMBL12436335 | 0.56 | DNMT3B (0.49) | DNMT3BDNMT1HNMTDOT1LCARM1 | |
| SCHEMBL14433645 | 0.56 | DNMT3B (0.49) | DNMT3BDNMT1HNMTDOT1LCARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771452-A4 | INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE | BIOCRYST PHARM INC (US) | 2009-07-15 | — | — | EP | disclosed |
| EP-1771452-A2 | INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006014913-A2 | INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND 5'METHYLTHIOADENOSINE/S-ADENOSYLHOMOCYSTEINE NUCLEOSIDASE | BIOCRYST PHARMACEUTICALS, INC. (US) | 2006-02-09 | — | — | WO | disclosed |