SCHEMBL4249157

SCHEMBL4249157

COc1ccc2c(c1)[N]C(=O)CO2

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.48
MAPT P10636 6/20 0.48
KDM4E B2RXH2 5/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
NPC1 O15118 4/20 0.48
RAB9A P51151 4/20 0.48
GAA P10253 3/20 0.48
ALOX12 P18054 3/20 0.48
HPGD P15428 1/20 0.48
TDP1 Q9NUW8 1/20 0.48
NFKB1 P19838 2/20 0.46
NFKB2 Q00653 2/20 0.46
RELA Q04206 2/20 0.46
HTT P42858 1/20 0.46
LMNA P02545 2/20 0.42
ALOX5 P09917 2/20 0.41
PPIB P23284 1/20 0.40
MTNR1A P48039 1/20 0.39
CYP19A1 P11511 1/20 0.39
APP P05067 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2072155 0.76 ALDH1A1 (0.44) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL315498 0.75 MAPT (0.53) MAPTKDM4ESMN1; SMN2NPC1RAB9A
SCHEMBL172911 0.71 MAPT (0.63) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL31017007 0.70 ALDH1A1 (0.41) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL341904 0.70 KDM4E (0.47) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL7304831 0.69 MAPT (0.56) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL14818250 0.69 MAPT (0.40) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1
SCHEMBL68899 0.68 MAPT (0.59) ALDH1A1MAPTKDM4ESMN1; SMN2LMNA
SCHEMBL31689707 0.68 MAPT (0.59) ALDH1A1MAPTKDM4ESMN1; SMN2LMNA
SCHEMBL705600 0.68 MAPT (0.64) ALDH1A1MAPTKDM4ESMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2049118-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SmithKline Beecham Corporation (US) 2009-04-22 EP disclosed
WO-2008011551-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SMITHKLINE BEECHAM CORPORATION (US) 2008-01-24 WO disclosed