Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055987 | 0.87 | NPC1 (0.57) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL68899 | 0.86 | MAPT (0.59) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL31689707 | 0.86 | MAPT (0.59) | MAPTKDM4EALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL26767783 | 0.85 | MAPT (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL769313 | 0.83 | NPC1 (0.54) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL29814619 | 0.80 | NPC1 (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL29817556 | 0.80 | ALDH1A1 (0.65) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL28827715 | 0.80 | ALDH1A1 (0.65) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL8029261 | 0.80 | NPC1 (0.52) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL87317 | 0.80 | ALDH1A1 (0.83) | MAPTKDM4EALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119528857-A | Synthesis method of 5-methoxy-3-benzofuranone | 上海毕臣生化科技有限公司 | 2025-02-28 | — | — | CN | claimed |
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-04-17 | — | — | US | disclosed |
| CN-119528857-A | Synthesis method of 5-methoxy-3-benzofuranone | 上海毕臣生化科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119528857-A | Synthesis method of 5-methoxy-3-benzofuranone | 上海毕臣生化科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119528857-A | Synthesis method of 5-methoxy-3-benzofuranone | 上海毕臣生化科技有限公司 | 2025-02-28 | — | — | CN | disclosed |
| US-12195478-B2 | Opioid receptor modulators | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-01-14 | — | — | US | disclosed |
| EP-4487913-A2 | OPIOID RECEPTOR MODULATORS | The Trustees Of Columbia University In The City Of New York (US) | 2025-01-08 | — | — | EP | disclosed |
| EP-3224261-B1 | OPIOID RECEPTOR MODULATORS | UNIV COLUMBIA (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2024146619-A1 | AURONE DERIVATIVE OR ANALOG, AND PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2024-07-11 | — | — | WO | disclosed |
| CN-118307504-A | Orange ketone derivative or analogue, preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2024-07-09 | — | — | CN | disclosed |
| WO-2004099191-A2 | BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AS SEROTONIN REUPTAKE INHIB ITORS | WYETH (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2003093258-A2 | NOVEL SPIRO KETONE AND CARBOXYLIC ACID DERIVATIVES AS SPECIFIC INHIBITORS FOR (PO3H2) SER/(PO3H2)THR-PRO-SPECIFIC PEPTIDYL-PROLYL-CIS/TRANS-ISOMERASES | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2003-11-13 | — | — | WO | disclosed |
| US-6147110-A | MELATONINERGIC AGENTS; SLEEP, EATING, CENTRAL NERVOUS SYSTEM, AND CARDIOVASCULAR DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-11-14 | — | — | US | disclosed |
| US-6071946-A | FOR TREATING DISORDERS OF THE MELATONINERGIC SYSTEM, SLEEP DISORDERS, CIRCADIAN RHYTHM DISORDERS | ADIR ET COMPAGNIE (FR) | 2000-06-06 | — | — | US | disclosed |
| US-5998461-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1999-12-07 | — | — | US | disclosed |
| EP-0926145-A1 | Napthalene compounds, method for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-06-30 | — | — | EP | disclosed |
| US-RE32196-E | PROPHYLACTIC CHEMOTHERAPY OF ALLERGIC CONDITIONS | LILLY INDUSTRIES LIMITED (GB) | 1986-07-01 | — | — | US | disclosed |
| US-4259340-A | PROPHYLACTIC CHEMOTHERAPY OF ALLERGIC CONDITIONS SUCH AS ASTHMA | LILLY INDUSTRIES LIMITED (GB) | 1981-03-31 | — | — | US | disclosed |
| US-4185110-A | ANTIALLERGENS | CIBA-GEIGY CORPORATION (US) | 1980-01-22 | — | — | US | disclosed |
| US-3961952-A | ELECTROPHOTOGRAPHY, SUPPORTS, COATINGS | ITEK CORPORATION (US) | 1976-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12195478-B2 | Opioid receptor modulators | OPRM1, OPRL1, OPRD1 | MAPT 3739/4885KDM4E 1372/4885ALDH1A1 2316/4885 |
| US-20250122213-A1 | OPIOID RECEPTOR MODULATORS | OPRM1, OPRL1, OPRD1 | MAPT 3739/4885KDM4E 1372/4885ALDH1A1 2316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.