Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1706646 | 0.76 | L3MBTL1 (0.65) | L3MBTL1KMT2AMEN1 | |
| SCHEMBL29681615 | 0.76 | L3MBTL1 (0.65) | L3MBTL1KMT2AMEN1 | |
| SCHEMBL1272091 | 0.76 | HSP90AA1 (0.40) | KCNH3NAMPTHPGDSHRH4P2RX7 | |
| SCHEMBL553439 | 0.75 | — | — | |
| SCHEMBL2753593 | 0.74 | PRMT1 (0.49) | L3MBTL1 | |
| SCHEMBL18157948 | 0.74 | KCNH3 (0.47) | KCNH3NAMPTHPGDSP2RX7 | |
| SCHEMBL2840809 | 0.73 | SMN1; SMN2 (0.59) | NAMPTL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL21880022 | 0.73 | KCNH3 (0.44) | KCNH3NAMPTHPGDSP2RX7 | |
| Hydrochloric Acid SCHEMBL30831440 | 0.73 | KCNH3 (0.44) | KCNH3NAMPTHPGDSP2RX7 | |
| SCHEMBL4250362 | 0.73 | HDAC3 (0.43) | NAMPTL3MBTL1KMT2AMEN1MALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049494-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | claimed |
| WO-2008008310-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | claimed |
| EP-2049494-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008008310-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2008-01-17 | — | — | WO | disclosed |
| EP-1735284-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | Pfizer Limited (GB) | 2006-12-27 | — | — | EP | disclosed |
| WO-2005090313-A1 | N-(1-ARYLPYRAZOL-4L)SULFONAMIDES AND THEIR USE AS PARASITICIDES | PFIZER LIMITED (GB) | 2005-09-29 | — | — | WO | disclosed |