Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 0.49 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258445 | 0.94 | ESR1 (0.43) | APPESR1BRD4MEN1KMT2A | |
| SCHEMBL4255711 | 0.83 | NPC1 (0.51) | APPESR1BRD4MEN1KMT2A | |
| SCHEMBL4257836 | 0.82 | ALDH1A1 (0.47) | APPESR1BRD4MEN1KMT2A | |
| SCHEMBL4258439 | 0.81 | ESR1 (0.61) | ESR1BRD4MEN1KMT2AALDH1A1 | |
| SCHEMBL4251146 | 0.79 | APP (0.45) | APPRAB9A | |
| SCHEMBL4254027 | 0.78 | ALDH1A1 (0.66) | ESR1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL4250573 | 0.77 | ALDH1A1 (0.50) | ESR1BRD4MEN1KMT2AALDH1A1 | |
| SCHEMBL4253650 | 0.77 | APP (0.46) | APPESR1BRD4MEN1KMT2A | |
| SCHEMBL4256208 | 0.76 | ALDH1A1 (0.50) | ESR1MEN1KMT2AALDH1A1GAA | |
| SCHEMBL22627171 | 0.74 | PKM (0.51) | ESR1BRD4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | claimed |
| WO-2009054653-A2 | ISOINDOLONES WITH HIGH BINDING AFFINITY TO BETA-AMYLOID AGGREGATES AND FIBRILS, AND ITS USE AND PREPARATION METHOD | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2009-04-30 | — | — | WO | disclosed |