Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 8/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250123 | 1.00 | KIF11 (0.39) | KIF11GNRHRBRD4SIGMAR1JAK2 | |
| SCHEMBL4248792 | 0.93 | GNRHR (0.38) | KIF11GNRHRBRD4SIGMAR1NPSR1 | |
| SCHEMBL4248789 | 0.93 | GNRHR (0.38) | KIF11GNRHRBRD4SIGMAR1NPSR1 | |
| SCHEMBL4252319 | 0.92 | BRD4 (0.39) | KIF11GNRHRBRD4NPSR1DYRK1A | |
| SCHEMBL4252323 | 0.92 | BRD4 (0.39) | KIF11GNRHRBRD4NPSR1DYRK1A | |
| SCHEMBL4252736 | 0.90 | KIF11 (0.40) | KIF11GNRHRBRD4SIGMAR1NPSR1 | |
| SCHEMBL4252742 | 0.90 | KIF11 (0.40) | KIF11GNRHRBRD4SIGMAR1NPSR1 | |
| SCHEMBL4250472 | 0.88 | GNRHR (0.39) | KIF11GNRHRBRD4LMNAHPGD | |
| SCHEMBL4250470 | 0.88 | GNRHR (0.39) | KIF11GNRHRBRD4LMNAHPGD | |
| SCHEMBL4252650 | 0.85 | GNRHR (0.36) | KIF11GNRHRBRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |