SCHEMBL4250595

SCHEMBL4250595

NC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2o1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYSLTR2 Q9NS75 9/20 0.68
CYSLTR1 Q9Y271 9/20 0.68
NR1H4 Q96RI1 2/20 0.68
ABCC4 O15439 1/20 0.68
ABCB11 O95342 1/20 0.68
PGR P06401 1/20 0.68
HTR1A P08908 1/20 0.68
AR P10275 1/20 0.68
CHRM1 P11229 1/20 0.68
DRD1 P21728 1/20 0.68
PTGS1 P23219 1/20 0.68
SLC6A2 P23975 1/20 0.68
PDE4A P27815 1/20 0.68
ADORA1 P30542 1/20 0.68
ADRA1A P35348 1/20 0.68
OPRM1 P35372 1/20 0.68
DRD3 P35462 1/20 0.68
SLC6A3 Q01959 1/20 0.68
GPR17 Q13304 1/20 0.68
GPR35 Q9HC97 8/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8121976 0.97 GPR35 (0.69) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL6956128 0.93 CYSLTR2 (0.66) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL7889217 0.92 CYSLTR2 (0.65) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL4255927 0.90 GPR35 (0.69) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL6956132 0.90 CYSLTR2 (0.67) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL6952491 0.89 CYSLTR2 (0.67) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL6962630 0.89 CYSLTR2 (0.66) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL4254475 0.88 GPR35 (0.69) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL8106555 0.88 GPR35 (0.66) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11
SCHEMBL8108390 0.87 GPR35 (0.70) CYSLTR2CYSLTR1NR1H4ABCC4ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed
EP-1380578-A1 PROCESS FOR PRODUCING NITRILE COMPOUND ONO PHARMACEUTICAL CO., LTD. (JP) 2004-01-14 EP disclosed
EP-0634409-B1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL CO (JP) 2000-04-26 EP disclosed
US-5659051-A Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-08-19 US disclosed
EP-0634409-A1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL CYSLTR2 3843/4885CYSLTR1 4183/4885NR1H4 478/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL CYSLTR2 3843/4885CYSLTR1 4183/4885NR1H4 478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.