SCHEMBL4254475

SCHEMBL4254475

CCOC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc(OCCCCc4ccccc4)cc3)c2o1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR35 Q9HC97 9/20 0.69
CYSLTR2 Q9NS75 9/20 0.64
CYSLTR1 Q9Y271 9/20 0.64
NR1H4 Q96RI1 2/20 0.64
ABCC4 O15439 1/20 0.64
ABCB11 O95342 1/20 0.64
PGR P06401 1/20 0.64
HTR1A P08908 1/20 0.64
AR P10275 1/20 0.64
CHRM1 P11229 1/20 0.64
DRD1 P21728 1/20 0.64
PTGS1 P23219 1/20 0.64
SLC6A2 P23975 1/20 0.64
PDE4A P27815 1/20 0.64
ADORA1 P30542 1/20 0.64
ADRA1A P35348 1/20 0.64
OPRM1 P35372 1/20 0.64
DRD3 P35462 1/20 0.64
SLC6A3 Q01959 1/20 0.64
GPR17 Q13304 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8107145 0.97 GPR35 (0.70) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL4255927 0.92 GPR35 (0.69) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL8106555 0.90 GPR35 (0.66) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL8108390 0.89 GPR35 (0.70) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL4250595 0.88 CYSLTR2 (0.68) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL6956132 0.87 CYSLTR2 (0.67) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL6956128 0.86 CYSLTR2 (0.66) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL7889217 0.85 CYSLTR2 (0.65) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL8121976 0.85 GPR35 (0.69) GPR35CYSLTR2CYSLTR1NR1H4ABCC4
SCHEMBL6952491 0.84 CYSLTR2 (0.67) GPR35CYSLTR2CYSLTR1NR1H4ABCC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed
EP-0634409-B1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL CO (JP) 2000-04-26 EP disclosed
US-5659051-A Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-08-19 US disclosed
EP-0634409-A1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-01-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885CYSLTR2 3843/4885CYSLTR1 4183/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GPR35 2693/4885CYSLTR2 3843/4885CYSLTR1 4183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.