Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.39 |
| ▸ | BRD4 | O60885 | 6/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 4/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | YES1 | P07947 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3965488 | 0.90 | CHRNA1 (0.41) | JAK2JAK3BRD4BRDTBRD2 | |
| SCHEMBL3971087 | 0.90 | AXL (0.41) | JAK2JAK3BRD4JAK1TYK2 | |
| SCHEMBL3969743 | 0.85 | AXL (0.42) | JAK2JAK3BRD4JAK1TYK2 | |
| SCHEMBL3971085 | 0.84 | AXL (0.51) | JAK2JAK3BRD4BRDTBRD2 | |
| SCHEMBL13881485 | 0.84 | JAK3 (0.56) | JAK2JAK3BRD4BRDTBRD2 | |
| SCHEMBL3965200 | 0.83 | AXL (0.41) | JAK2JAK3BRD4BRDTBRD2 | |
| SCHEMBL3967985 | 0.82 | AXL (0.39) | JAK2JAK3BRD4JAK1TYK2 | |
| SCHEMBL3967433 | 0.82 | AXL (0.44) | JAK2JAK3BRD4JAK1TYK2 | |
| SCHEMBL3967352 | 0.80 | CHEK1 (0.39) | JAK2JAK3BRD4BRDTSYK | |
| SCHEMBL3966066 | 0.80 | AXL (0.41) | JAK2JAK3BRD4BRDTBRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |