SCHEMBL4251650

SCHEMBL4251650

O=C(O)/C=C(\Oc1cccc([N+](=O)[O-])c1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
F2 P00734 1/20 0.52
HGFAC Q04756 1/20 0.47
TP53 P04637 1/20 0.46
MAPT P10636 2/20 0.46
ALOX5 P09917 3/20 0.45
TSHR P16473 4/20 0.44
LMNA P02545 1/20 0.44
ALDH1A1 P00352 5/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
ALOX15 P16050 1/20 0.42
NFE2L2 Q16236 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4250509 1.00 F2 (0.52) F2HGFACTP53MAPTALOX5
SCHEMBL4250502 1.00 F2 (0.52) F2HGFACTP53MAPTALOX5
SCHEMBL4253707 0.82 GAA (0.51) HGFACMAPTALDH1A1CES2CES1
SCHEMBL4258068 0.82 GAA (0.51) HGFACMAPTALDH1A1CES2CES1
SCHEMBL4253701 0.82 GAA (0.51) HGFACMAPTALDH1A1CES2CES1
SCHEMBL11195246 0.80 F2 (0.61) F2HGFACTP53MAPTALOX5
SCHEMBL2955782 0.78 F2 (0.63) F2HGFACTP53MAPTALOX5
SCHEMBL7929197 0.78 F2 (0.63) F2HGFACTP53MAPTALOX5
SCHEMBL4246726 0.77 ALDH1A1 (0.50) F2HGFACMAPTALOX5LMNA
SCHEMBL4246720 0.77 ALDH1A1 (0.50) F2HGFACMAPTALOX5LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL F2 352/4885HGFAC 3965/4885TP53 2582/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL F2 352/4885HGFAC 3965/4885TP53 2582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.