SCHEMBL4253701

SCHEMBL4253701

O=C(O)/C=C(\Oc1ccc([N+](=O)[O-])cc1)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.51
BCL9 O00512 1/20 0.49
CTNNB1 P35222 1/20 0.49
ALDH1A1 P00352 3/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
KMT2A Q03164 5/20 0.48
PKM P14618 1/20 0.48
MEN1 O00255 3/20 0.47
SRD5A2 P31213 1/20 0.45
TDP1 Q9NUW8 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CES2 O00748 1/20 0.44
CES1 P23141 1/20 0.44
MAPT P10636 2/20 0.43
MGLL Q99685 1/20 0.43
NPC1 O15118 1/20 0.43
MAPK1 P28482 1/20 0.43
RAB9A P51151 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4258068 1.00 GAA (0.51) GAABCL9CTNNB1ALDH1A1SMN1; SMN2
SCHEMBL4253707 1.00 GAA (0.51) GAABCL9CTNNB1ALDH1A1SMN1; SMN2
SCHEMBL4250509 0.82 F2 (0.52) ALDH1A1CES2CES1MAPTHGFAC
SCHEMBL4251650 0.82 F2 (0.52) ALDH1A1CES2CES1MAPTHGFAC
SCHEMBL4250502 0.82 F2 (0.52) ALDH1A1CES2CES1MAPTHGFAC
SCHEMBL8578508 0.78 GAA (0.59) GAABCL9CTNNB1ALDH1A1SMN1; SMN2
SCHEMBL8228620 0.77 TDP1 (0.42) ALDH1A1TDP1MAPT
SCHEMBL26375 0.77 GAA (0.62) GAABCL9CTNNB1ALDH1A1SMN1; SMN2
SCHEMBL10792060 0.77 TDP1 (0.42) ALDH1A1TDP1MAPT
SCHEMBL9685241 0.77 TDP1 (0.42) ALDH1A1TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GAA 2812/4885BCL9 4330/4885CTNNB1 1544/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL GAA 2812/4885BCL9 4330/4885CTNNB1 1544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.