Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | CTSK | P43235 | 6/20 | 0.54 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.54 |
| ▸ | ELANE | P08246 | 2/20 | 0.53 |
| ▸ | CTSS | P25774 | 6/20 | 0.52 |
| ▸ | CTSL | P07711 | 5/20 | 0.52 |
| ▸ | CTSB | P07858 | 3/20 | 0.51 |
| ▸ | PRTN3 | P24158 | 2/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251984 | 1.00 | ATM (0.57) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL13197150 | 0.85 | ATM (0.54) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL14257005 | 0.85 | ATM (0.54) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL13534727 | 0.84 | NPC1 (0.65) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL6407665 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL13572927 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL5268187 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL398460 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL1547277 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS | |
| SCHEMBL14999596 | 0.84 | ATM (0.59) | ATMCTSKCTRB1ELANECTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3317277-B1 | SOMATOSTATIN MODULATORS AND USES THEREOF | CRINETICS PHARMACEUTICALS INC (US) | 2021-01-20 | — | — | EP | disclosed |
| US-9957267-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2018-05-01 | — | — | US | disclosed |
| US-9957267-B2 | Somatostatin modulators and uses thereof | Crinetics Pharmaceuticals, Inc. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20170002001-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2017-01-05 | — | — | US | disclosed |
| WO-2017003723-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. (US) | 2017-01-05 | — | — | WO | disclosed |
| US-20170002001-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | Crinetics Pharmaceuticals, Inc. | 2017-01-05 | — | — | US | disclosed |
| US-20090088569-A1 | 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | ECKHARDT MATTHIAS | 2009-04-02 | — | — | US | disclosed |
| US-7476671-B2 | 2-amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-01-13 | — | — | US | disclosed |
| US-20070088038-A1 | 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | ECKHARDT MATTHIAS | 2007-04-19 | — | — | US | disclosed |
| US-7179809-B2 | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-20 | — | — | US | disclosed |
| EP-1740589-A1 | NOVEL 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES AND 2-AMINO-IMIDAZO[4,5-C]PYRIDIN-4-ONES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-10 | — | — | EP | disclosed |
| US-20050234235-A1 | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | US | disclosed |
| WO-2005097798-A1 | NOVEL 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES AND 2-AMINO-IMIDAZO[4,5-C]PYRIDIN-4-ONES, PRODUCTION AND USE THEREOF AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-10-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234235-A1 | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions | DPP4, DPP3, DPP8 | ATM 4644/4885CTSK 1168/4885CTRB1 722/4885 |
| US-20090088569-A1 | 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP4, DPP3, DPP7 | ATM 4689/4885CTSK 1058/4885CTRB1 679/4885 |
| US-20070088038-A1 | 2-AMINO-IMIDAZO[4,5-D]PYRIDAZIN-4-ONES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | DPP4, DPP3, DPP8 | ATM 4644/4885CTSK 1168/4885CTRB1 722/4885 |
| US-20170002001-A1 | SOMATOSTATIN MODULATORS AND USES THEREOF | SSTR5, SSTR2, SSTR4 | ATM 3578/4885CTSK 617/4885CTRB1 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.