SCHEMBL4252355

SCHEMBL4252355

COC(=O)c1cc(=O)c2c(N)cccc2o1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.52
ESR1 P03372 1/20 0.50
ESR2 Q92731 1/20 0.50
LMNA P02545 2/20 0.45
MAPT P10636 3/20 0.44
GAA P10253 1/20 0.44
MAOB P27338 1/20 0.44
ALDH1A1 P00352 2/20 0.44
CFTR P13569 1/20 0.44
HSD17B10 Q99714 1/20 0.44
HPGD P15428 1/20 0.42
GPR35 Q9HC97 3/20 0.42
TDP1 Q9NUW8 2/20 0.42
POLH Q9Y253 1/20 0.42
ATM Q13315 1/20 0.42
KMT2A Q03164 3/20 0.41
ABCG2 Q9UNQ0 1/20 0.41
MEN1 O00255 2/20 0.40
CASP3 P42574 1/20 0.40
SENP7 Q9BQF6 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4254657 0.85 AKR1B1 (0.56) KDM4EESR1ESR2LMNAMAPT
SCHEMBL20886780 0.85 KDM4E (0.52) KDM4ELMNAMAPTGAAMAOB
SCHEMBL15821014 0.85 POLH (0.58) KDM4EMAPTALDH1A1HPGDPOLH
SCHEMBL4251548 0.84 AKR1B1 (0.56) KDM4EESR1ESR2MAPTGAA
SCHEMBL4248824 0.84 ESR1 (0.47) KDM4EESR1ESR2LMNAMAPT
SCHEMBL29393931 0.84 ALDH1A1 (0.57) KDM4EESR1ESR2LMNAMAPT
SCHEMBL4255934 0.82 MAOB (0.68) KDM4EESR1ESR2MAPTMAOB
SCHEMBL4252558 0.82 MAOB (0.48) ESR1ESR2LMNAMAPTGAA
SCHEMBL27878925 0.81 KDM4E (0.53) KDM4EMAPTGAAMAOBALDH1A1
SCHEMBL4248424 0.81 KDM4E (0.60) KDM4EESR1ESR2LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885ESR1 143/4885ESR2 248/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL KDM4E 978/4885ESR1 143/4885ESR2 248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.