Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 14/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255912 | 0.94 | KIF11 (0.40) | KIF11ALDH1A1TDP1 | |
| SCHEMBL4245624 | 0.94 | KIF11 (0.41) | KIF11ALDH1A1 | |
| SCHEMBL4255894 | 0.93 | KIF11 (0.36) | KIF11ALDH1A1 | |
| SCHEMBL4245137 | 0.92 | KIF11 (0.45) | KIF11ALDH1A1TDP1 | |
| SCHEMBL4255872 | 0.91 | PDE1B (0.38) | KIF11ALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL4251311 | 0.89 | KIF11 (0.36) | KIF11ALDH1A1MEN1KMT2A | |
| SCHEMBL4249153 | 0.89 | KIF11 (0.40) | KIF11TDP1 | |
| SCHEMBL4252366 | 0.79 | KIF11 (0.44) | KIF11 | |
| SCHEMBL4252370 | 0.79 | KIF11 (0.37) | KIF11ALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL4055444 | 0.79 | KIF11 (0.39) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |