Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 6/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KLK1 | P06870 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4245624 | 0.93 | KIF11 (0.41) | ALDH1A1KIF11 | |
| SCHEMBL4255912 | 0.93 | KIF11 (0.40) | ALDH1A1KIF11TDP1 | |
| SCHEMBL4252369 | 0.91 | KIF11 (0.37) | ACHEALDH1A1KIF11KMT2AMEN1 | |
| SCHEMBL4245137 | 0.91 | KIF11 (0.45) | ALDH1A1KIF11CHRM2CHRM3TDP1 | |
| SCHEMBL4255894 | 0.90 | KIF11 (0.36) | ALDH1A1KIF11 | |
| SCHEMBL4251311 | 0.88 | KIF11 (0.36) | ALDH1A1KIF11KMT2AMEN1 | |
| SCHEMBL4249153 | 0.88 | KIF11 (0.40) | KIF11TDP1 | |
| SCHEMBL4255871 | 0.80 | KIF11 (0.43) | PDE1BKIF11 | |
| SCHEMBL4255875 | 0.79 | PTGDR2 (0.41) | PDE1BACHEALDH1A1KIF11KMT2A | |
| SCHEMBL4055444 | 0.77 | KIF11 (0.39) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035426-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007144384-A1 | PYRAZOLOPYRIMIDONES | 4SC AG (DE) | 2007-12-21 | — | — | WO | disclosed |