Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4243404 | 0.79 | MAOB (0.46) | MAPTSMN1; SMN2LMNAKDM4EMAOB | |
| SCHEMBL4243406 | 0.79 | MAOB (0.46) | MAPTSMN1; SMN2LMNAKDM4EMAOB | |
| SCHEMBL4473051 | 0.78 | MAOB (0.45) | MAPTSMN1; SMN2LMNAKDM4EMAOB | |
| SCHEMBL4473057 | 0.78 | MAOB (0.45) | MAPTSMN1; SMN2LMNAKDM4EMAOB | |
| SCHEMBL9518819 | 0.73 | NFKB1 (0.50) | MAPTSMN1; SMN2LMNAKDM4EMAOB | |
| SCHEMBL10984242 | 0.73 | BACE1 (0.56) | MAPTSMN1; SMN2LMNAMAOBNFKB1 | |
| SCHEMBL28299341 | 0.72 | TSHR (0.71) | TP53L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL4469618 | 0.70 | LMNA (0.49) | MAPTLMNAALDH1A1MAOBNFKB1 | |
| SCHEMBL4469625 | 0.70 | LMNA (0.49) | MAPTLMNAALDH1A1MAOBNFKB1 | |
| SCHEMBL4469622 | 0.70 | LMNA (0.49) | MAPTLMNAALDH1A1MAOBNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773833-A4 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL MYERS SQUIBB CO (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-1773833-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006019940-A2 | PYRROLO(OXO)QUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |