SCHEMBL4253122

SCHEMBL4253122

O=S(=O)(CS(=O)(=O)c1cccc(Cl)c1)c1cccc(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 6/20 0.50
PGR P06401 5/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50
CYP2D6 P10635 1/20 0.50
CYP2C19 P33261 1/20 0.50
MEN1 O00255 1/20 0.50
ALDH1A1 P00352 1/20 0.50
KMT2A Q03164 1/20 0.50
MMP2 P08253 1/20 0.49
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
NFE2L2 Q16236 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12959609 0.85 PSIP1 (0.56) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL30487713 0.85 PSIP1 (0.56) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL18332339 0.83 CYP1A2 (0.48) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL11816653 0.83 CYP1A2 (0.48) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL6097587 0.80 PTGDR2 (0.48) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL22615661 0.80 PTGDR2 (0.49) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL31435391 0.79 AKR1B1 (0.56) PGRCYP3A4MEN1ALDH1A1KMT2A
SCHEMBL2199161 0.79 AKR1B1 (0.56) PGRCYP3A4MEN1ALDH1A1KMT2A
SCHEMBL23521618 0.79 CYP1A2 (0.48) FBP1PGRCYP1A2CYP3A4CYP2D6
SCHEMBL7140183 0.79 CYP1A2 (0.44) FBP1PGRCYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7638654-B2 1-fluoro-1, 1-bis-(phenylsulfonyl)methane and production method thereof NAGOYA INSTITUTE OF TECHNOLOGY (JP) 2009-12-29 US disclosed
US-20090131723-A1 1-Fluoro-1,1-Bis-(Phenylsulfonyl)Methane and Production Method Thereof TOSOH F-TECH, INC. (JP) 2009-05-21 US disclosed
EP-1992612-A1 1-FLUORO-1,1-BIS(PHENYLSULFONYL)METHANE AND METHOD FOR PRODUCING SAME NAGOYA INSTITUTE OF TECHNOLOGY (JP) 2008-11-19 EP disclosed
EP-0654149-B1 POSITIVE-ACTING RADIATION-SENSITIVE MIXTURE AND RECORDING MATERIAL PRODUCED THEREWITH HOECHST AG (DE) 1997-02-05 EP disclosed
EP-0654149-A1 POSITIVE-ACTING RADIATION-SENSITIVE MIXTURE AND RECORDING MATERIAL PRODUCED THEREWITH. HOECHST AG (DE) 1995-05-24 EP disclosed
WO-1994003837-A1 POSITIVE-ACTING RADIATION-SENSITIVE MIXTURE AND RECORDING MATERIAL PRODUCED THEREWITH HOECHST AKTIENGESELLSCHAFT (DE) 1994-02-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090131723-A1 1-Fluoro-1,1-Bis-(Phenylsulfonyl)Methane and Production Method Thereof CYP2S1, ARSA, MSMO1 FBP1 145/4885PGR 4170/4885CYP1A2 78/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.