SCHEMBL4253143

SCHEMBL4253143

CCNS(=O)(=O)c1ccc(Cn2nc(C(N)=O)c3ccccc32)cc1

nearest known ligand 0.49

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 1/20 0.48
MCL1 Q07820 1/20 0.48
ALDH1A1 P00352 5/20 0.47
LMNA P02545 2/20 0.47
PTGER4 P35408 7/20 0.47
CYP2D6 P10635 1/20 0.42
KMT2A Q03164 1/20 0.42
PARP1 P09874 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
NCOR2 Q9Y618 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13671617 0.85 CNR1 (0.50) CNR1MCL1PTGER4CYP2D6PARP1
SCHEMBL4253145 0.84 ALDH1A1 (0.42) CNR1MCL1ALDH1A1LMNAPTGER4
SCHEMBL4250971 0.83 CNR1 (0.46) CNR1MCL1ALDH1A1LMNAPTGER4
SCHEMBL4252020 0.82 CNR1 (0.48) CNR1MCL1ALDH1A1PTGER4CYP2D6
SCHEMBL4245639 0.81 CA12 (0.45) CNR1MCL1PTGER4PARP1HDAC3
SCHEMBL31647277 0.80 PTGER4 (0.60) CNR1ALDH1A1LMNAPTGER4CYP2D6
SCHEMBL3775553 0.80 PTGER4 (0.60) CNR1ALDH1A1LMNAPTGER4CYP2D6
SCHEMBL24273625 0.79 PTGER4 (0.62) CNR1ALDH1A1LMNAPTGER4CYP2D6
SCHEMBL6114223 0.77 PTGER4 (0.57) CNR1PTGER4CYP2D6KMT2AHDAC3
SCHEMBL8591344 0.77 PTGER4 (0.52) CNR1ALDH1A1LMNAPTGER4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005056532-A1 INDAZOLE DERIVATIVES WHICH INTERACT WITH THE G-PROTEIN COUPLED RECEPTOR FAMILY BIOFOCUS DISCOVERY LIMITED (GB) 2005-06-23 WO claimed
EP-2117577-A1 G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS Arena Pharmaceuticals, Inc. (US) 2009-11-18 EP disclosed
WO-2008085888-A1 G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS ARENA PHARMACEUTICALS, INC. (US) 2008-07-17 WO disclosed
WO-2005056532-A1 INDAZOLE DERIVATIVES WHICH INTERACT WITH THE G-PROTEIN COUPLED RECEPTOR FAMILY BIOFOCUS DISCOVERY LIMITED (GB) 2005-06-23 WO disclosed