SCHEMBL4253145

SCHEMBL4253145

CCNS(=O)(=O)c1ccc(Cn2nc(N)c3ccccc32)cc1

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.42
LMNA P02545 2/20 0.42
KMT2A Q03164 2/20 0.40
MCL1 Q07820 1/20 0.40
HDAC3 O15379 1/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
HDAC10 Q969S8 1/20 0.39
HDAC8 Q9BY41 1/20 0.39
HDAC6 Q9UBN7 1/20 0.39
NCOR2 Q9Y618 1/20 0.39
MEN1 O00255 1/20 0.38
ATM Q13315 1/20 0.38
POLB P06746 1/20 0.38
CYP2C9 P11712 1/20 0.38
CNR1 P21554 2/20 0.38
CNR2 P34972 1/20 0.38
PTGER4 P35408 1/20 0.38
BUB1 O43683 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4253143 0.84 CNR1 (0.48) ALDH1A1LMNAKMT2AMCL1HDAC3
SCHEMBL4250973 0.81 PHOSPHO1 (0.45) ALDH1A1LMNAKMT2AHDAC3HDAC1
SCHEMBL4252022 0.81 HDAC3 (0.42) ALDH1A1LMNAMCL1HDAC3HDAC1
SCHEMBL4245643 0.79 CA12 (0.43) ALDH1A1HDAC3HDAC1HDAC2HDAC10
SCHEMBL17038835 0.76 P2RX4 (0.49) ALDH1A1LMNAKMT2AMEN1CYP2C9
SCHEMBL30694971 0.76 P2RX4 (0.49) ALDH1A1LMNAKMT2AMEN1CYP2C9
SCHEMBL958473 0.76 CNR1 (0.58) ALDH1A1LMNAPOLBCYP2C9CNR1
SCHEMBL29459606 0.75 TDP1 (0.50) ALDH1A1LMNAKMT2AMEN1POLB
SCHEMBL17039004 0.75 TDP1 (0.50) ALDH1A1LMNAKMT2AMEN1POLB
SCHEMBL6852970 0.74 KMT2A (0.49) ALDH1A1KMT2AHDAC1MEN1CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005056532-A1 INDAZOLE DERIVATIVES WHICH INTERACT WITH THE G-PROTEIN COUPLED RECEPTOR FAMILY BIOFOCUS DISCOVERY LIMITED (GB) 2005-06-23 WO claimed
EP-2117577-A1 G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS Arena Pharmaceuticals, Inc. (US) 2009-11-18 EP disclosed
WO-2008085888-A1 G PROTEIN-COUPLED RECEPTOR AND MODULATORS THEREOF FOR THE TREATMENT OF GABA-RELATED NEUROLOGICAL DISORDERS INCLUDING SLEEP-RELATED DISORDERS ARENA PHARMACEUTICALS, INC. (US) 2008-07-17 WO disclosed
WO-2005056532-A1 INDAZOLE DERIVATIVES WHICH INTERACT WITH THE G-PROTEIN COUPLED RECEPTOR FAMILY BIOFOCUS DISCOVERY LIMITED (GB) 2005-06-23 WO disclosed