Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ATM | Q13315 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442609 | 0.90 | MAPT (0.75) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4250281 | 0.87 | NPC1 (0.53) | MAPTL3MBTL1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4247509 | 0.83 | MAPT (0.48) | MAPTL3MBTL1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4258464 | 0.83 | MAPT (0.49) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4252430 | 0.83 | NPC1 (0.53) | HPGDSMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL4250397 | 0.82 | MAPT (0.47) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4247486 | 0.82 | CHRNB2 (0.47) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4252991 | 0.82 | KMT2A (0.56) | MAPTL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4248905 | 0.82 | NPC1 (0.51) | MAPTL3MBTL1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4254739 | 0.81 | BRD4 (0.49) | MAPTL3MBTL1ALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | MAPT 2673/4885L3MBTL1 1527/4885ALDH1A1 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.