Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228620 | 1.00 | TDP1 (0.42) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL10792060 | 1.00 | TDP1 (0.42) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL9683417 | 0.82 | KMT2A (0.41) | ATMALOX15KDM4EALDH1A1 | |
| SCHEMBL9683421 | 0.82 | KMT2A (0.41) | ATMALOX15KDM4EALDH1A1 | |
| SCHEMBL1004802 | 0.81 | ATM (0.44) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL1004800 | 0.81 | ATM (0.44) | TDP1ATML3MBTL1ALOX15HPGD | |
| SCHEMBL11128324 | 0.80 | HTT (0.36) | TDP1ATML3MBTL1ALOX15MAOB | |
| SCHEMBL9018477 | 0.80 | KMT2A (0.49) | MAPTALDH1A1 | |
| SCHEMBL6191253 | 0.80 | NR4A1 (0.51) | ALDH1A1 | |
| SCHEMBL6191252 | 0.80 | NR4A1 (0.51) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-1221374-A | — | — | None | — | — | JP | disclosed |
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-07-31 | — | — | US | disclosed |
| US-7365095-B2 | Chromane and chromene derivatives and uses thereof | WYETH (US) | 2008-04-29 | — | — | US | disclosed |
| US-20080039639-A1 | Chromane and chromene derivatives and uses thereof | WYETH (US) | 2008-02-14 | — | — | US | disclosed |
| US-5171865-A | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1992-12-15 | — | — | US | disclosed |
| EP-0331078-A2 | Process for the preparation of optically active 4-oxo-1-benzopyran-2-carboxylic acid derivatives and intermediates thereof | SANWA KAGAKU KENKYUSHO CO., LTD. (JP) | 1989-09-06 | — | — | EP | disclosed |
| JP-H01221374-A | PRODUCTION OF 4-OXO-1-BENZOPYRAN-2-CARBOXYLIC ACID DERIVATIVE HAVING OPTICAL ACTIVITY, INTERMEDIATE FOR SYNTHESIZING SAID DERIVATIVE AND PRODUCTION OF SAID INTERMEDIATE | SANWA KAGAKU KENKYUSHO CO LTD | 1989-09-04 | — | — | JP | disclosed |
| EP-0123321-B1 | PROCESS FOR RETICULATING ORGANOPOLYSILOXANE COMPOSITIONS | Wacker-Chemie GmbH (DE) | 1987-03-25 | — | — | EP | disclosed |
| EP-0123321-A2 | Process for reticulating organopolysiloxane compositions | Wacker-Chemie GmbH (DE) | 1984-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | HTR1A, HTR2C, CHRM1 | TDP1 1654/4885ATM 1759/4885L3MBTL1 3943/4885 |
| US-20080039639-A1 | Chromane and chromene derivatives and uses thereof | HTR1A, CHRM1, HTR2C | TDP1 1930/4885ATM 1846/4885L3MBTL1 4059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.