Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 11/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 11/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL443086 | 0.90 | HDAC1 (0.47) | ALDH1A1HPGDPPARGHDAC3HDAC4 | |
| SCHEMBL443087 | 0.90 | HDAC1 (0.47) | ALDH1A1HPGDPPARGHDAC3HDAC4 | |
| SCHEMBL4254174 | 0.87 | PPARG (0.52) | ALDH1A1PPARGHDAC3HDAC4HDAC1 | |
| SCHEMBL4255571 | 0.87 | PPARG (0.52) | ALDH1A1PPARGHDAC3HDAC4HDAC1 | |
| SCHEMBL4251079 | 0.85 | PPARG (0.46) | PPARGHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4250725 | 0.84 | TAS1R3 (0.55) | PPARGHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4251095 | 0.84 | TAS1R3 (0.55) | PPARGHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4251108 | 0.82 | TAS1R3 (0.59) | ALDH1A1PPARGHDAC3HDAC4HDAC1 | |
| SCHEMBL4255209 | 0.82 | TAS1R3 (0.59) | ALDH1A1PPARGHDAC3HDAC4HDAC1 | |
| SCHEMBL4251049 | 0.82 | PPARG (0.43) | ALDH1A1PPARGHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023798-A1 | THIOHYDROXAMATES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC8, HDAC3 | ALDH1A1 601/4885HPGD 351/4885PPARG 513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.