⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29537786 | 0.64 | — | — | |
| SCHEMBL28126490 | 0.61 | — | — | |
| SCHEMBL4268178 | 0.59 | — | — | |
| SCHEMBL918294 | 0.55 | ADRA2A (0.31) | — | |
| SCHEMBL10381356 | 0.55 | KDM4E (0.32) | — | |
| SCHEMBL9218651 | 0.52 | — | — | |
| SCHEMBL1065030 | 0.50 | — | — | |
| SCHEMBL3273863 | 0.50 | — | — | |
| SCHEMBL6841696 | 0.50 | — | — | |
| SCHEMBL7456590 | 0.50 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999024435-A1 | AZACHROMACHALIME DERIVATIVES HAVING HYPOTENSIVE ACTIVITY | EGIS Gyógyszergyár Rt. (HU) | 1999-05-20 | — | — | WO | claimed |
| US-8349864-B2 | Pyrano [3,2-C] pyridones and related heterocyclic compounds as pharmaceutical agents for treating disorders responsive to apoptosis, antiproliferation or vascular disruption, and the use thereof | NEW MEXICO TECHNICAL RESEARCH FOUNDATION (US) | 2013-01-08 | — | — | US | disclosed |
| US-20090247566-A1 | Pyrano [3,2-C] Pyridones and Related Heterocyclic Compounds as Pharmaceutical Agents for Treating Disorders Responsive to Apoptosis, Antiproliferation or Vascular Disruption, and the Use Thereof | NEW MEXICO TECHNICAL RESEARCH FOUNDATION | 2009-10-01 | — | — | US | disclosed |
| WO-1999024435-A1 | AZACHROMACHALIME DERIVATIVES HAVING HYPOTENSIVE ACTIVITY | EGIS Gyógyszergyár Rt. (HU) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999024435-A1 | AZACHROMACHALIME DERIVATIVES HAVING HYPOTENSIVE ACTIVITY | EGIS Gyógyszergyár Rt. (HU) | 1999-05-20 | — | — | WO | disclosed |
| EP-0427606-B1 | 4-Amidino chromane and 4-amidino pyrano(3,2-c)pyridine derivatives, process for preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1995-02-01 | — | — | EP | disclosed |
| US-5116849-A | 4-AMIDINO CHROMAN AND 4-AMIDINO PYRANO (3,2-C) PYRIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANOFI (FR) | 1992-05-26 | — | — | US | disclosed |
| EP-0205292-B1 | Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1991-11-06 | — | — | EP | disclosed |
| EP-0427606-A1 | 4-Amidino chromane and 4-amidino pyrano(3,2-c)pyridine derivatives, process for preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1991-05-15 | — | — | EP | disclosed |
| EP-0373204-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1990-06-20 | — | — | EP | disclosed |
| WO-1989011477-A1 | BENZOXEPINE AND RELATED COMPOUNDS | BEECHAM GROUP PLC (GB) | 1989-11-30 | — | — | WO | disclosed |
| WO-1989010925-A1 | NOVEL COMPOUNDS AND TREATMENT | BEECHAM GROUP PLC (GB) | 1989-11-16 | — | — | WO | disclosed |
| EP-0205292-A2 | Pyrano[3,2-c]pyridine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1986-12-17 | — | — | EP | disclosed |