Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 6/20 | 0.39 |
| ▸ | TPO | P07202 | 4/20 | 0.39 |
| ▸ | PDE4A | P27815 | 8/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PNP | P00491 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775036 | 0.84 | ADORA2A (0.50) | MPOTPOPDE4APDE4BPDE4C | |
| SCHEMBL1777507 | 0.81 | XDH (0.51) | HPGDHSD17B10XDH | |
| SCHEMBL1774836 | 0.76 | ADORA2A (0.54) | MPOTPOPDE4APDE4BPDE4C | |
| SCHEMBL4254819 | 0.74 | — | — | |
| SCHEMBL1776404 | 0.73 | XDH (0.48) | HPGDHSD17B10XDH | |
| SCHEMBL1775064 | 0.72 | MPO (0.54) | MPOTPOPDE4APDE4BPDE4C | |
| SCHEMBL1776355 | 0.68 | XDH (0.47) | XDH | |
| SCHEMBL1373494 | 0.66 | PDE4A (0.74) | MPOTPOPDE4APDE4BPDE4C | |
| SCHEMBL1460898 | 0.64 | PDE4A (0.75) | MPOTPOPDE4APDE4BPDE4C | |
| SCHEMBL562472 | 0.63 | PDE4A (0.69) | MPOTPOPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029598-A1 | 2-THIOXANTHINE DERIVATIVES ACTING AS MPO-INHIBITORS | Astra Zeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007142576-A1 | 2-THIOXANTHINE DERIVATIVES ACTING AS MPO-INHIBITORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |