Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 9/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.71 |
| ▸ | MAPT | P10636 | 8/20 | 0.71 |
| ▸ | SENP6 | Q9GZR1 | 6/20 | 0.71 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | NSD2 | O96028 | 2/20 | 0.63 |
| ▸ | MPI | P34949 | 1/20 | 0.63 |
| ▸ | APAF1 | O14727 | 4/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.60 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.57 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254859 | 1.00 | LMNA (0.75) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL11900273 | 0.83 | KDM4E (1.00) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL1443164 | 0.83 | KDM4E (1.00) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL18330253 | 0.83 | MAPT (1.00) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL11900788 | 0.83 | MAPT (1.00) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL11981638 | 0.83 | MAPT (1.00) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL13576487 | 0.78 | LMNA (0.81) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| Water SCHEMBL17200138 | 0.75 | KDM4E (0.74) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL1443113 | 0.74 | MAPT (0.82) | LMNAKDM4EMAPTSENP6SENP7 | |
| SCHEMBL11981855 | 0.74 | MAPT (0.82) | LMNAKDM4EMAPTSENP6SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | THE JOHNS HOPKINS UNIVERSITY (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215765-A1 | Neuroprotective compounds for treating optic neuropathies | NLN, GAP43, AIFM1 | LMNA 1628/4885KDM4E 4215/4885MAPT 561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.