Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | PAK4 | O96013 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | LTK | P29376 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4251723 | 0.88 | JAK2 (0.46) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL13883576 | 0.81 | JAK2 (0.40) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL4081376 | 0.80 | JAK2 (0.40) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL4255795 | 0.79 | JAK1 (0.38) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL13883496 | 0.79 | JAK2 (0.38) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL13883718 | 0.78 | AXL (0.38) | JAK2TNIKJAK1TTK | |
| SCHEMBL13883557 | 0.78 | IKBKB (0.40) | JAK2LMNAL3MBTL1PTK2TNIK | |
| SCHEMBL3964284 | 0.77 | JAK2 (0.37) | JAK2LMNAL3MBTL1LRRK2PTK2 | |
| SCHEMBL4409833 | 0.76 | TNIK (0.37) | JAK2LRRK2PTK2CHEK1AURKA | |
| SCHEMBL3973621 | 0.75 | JAK2 (0.38) | JAK2LMNAL3MBTL1LRRK2PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009055674-A1 | PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-04-30 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |