Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 7/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.36 |
| ▸ | PAK4 | O96013 | 3/20 | 0.36 |
| ▸ | RET | P07949 | 3/20 | 0.36 |
| ▸ | LTK | P29376 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.36 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.36 |
| ▸ | MST1R | Q04912 | 3/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255795 | 0.90 | JAK1 (0.38) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL13883576 | 0.84 | JAK2 (0.40) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL13883514 | 0.82 | LRRK2 (0.35) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL13883718 | 0.81 | AXL (0.38) | TNIKJAK2TTKJAK1 | |
| SCHEMBL4407227 | 0.79 | JAK1 (0.38) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL13883496 | 0.79 | JAK2 (0.38) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL13883626 | 0.78 | IKBKB (0.41) | TNIKJAK2AURKARETKDR | |
| SCHEMBL3971650 | 0.78 | TNIK (0.39) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL3973621 | 0.78 | JAK2 (0.38) | TNIKJAK2LRRK2PTK2AURKA | |
| SCHEMBL4081376 | 0.78 | JAK2 (0.40) | TNIKJAK2LRRK2PTK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |