Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.34 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.34 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.31 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.30 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255105 | 1.00 | GRIK1 (0.37) | GRIK1MAOAMAOBAKR1C3AKR1C1 | |
| SCHEMBL2654404 | 0.84 | AKR1C3 (0.50) | AKR1C3AKR1C1AKR1C2KMT2AHAO1 | |
| SCHEMBL2654402 | 0.84 | AKR1C3 (0.50) | AKR1C3AKR1C1AKR1C2KMT2AHAO1 | |
| SCHEMBL2652741 | 0.82 | AKR1C3 (0.49) | AKR1C3AKR1C1AKR1C2KMT2AHAO1 | |
| SCHEMBL2652745 | 0.82 | AKR1C3 (0.49) | AKR1C3AKR1C1AKR1C2KMT2AHAO1 | |
| SCHEMBL4265493 | 0.80 | RAB9A (0.37) | MAOAMAOBKMT2A | |
| SCHEMBL4265499 | 0.80 | RAB9A (0.37) | MAOAMAOBKMT2A | |
| SCHEMBL2652614 | 0.80 | DDB1 (0.39) | DDB1CRBNKMT2A | |
| SCHEMBL2652611 | 0.80 | DDB1 (0.39) | DDB1CRBNKMT2A | |
| SCHEMBL4257859 | 0.79 | NPC1 (0.33) | GRIK1AKR1C3AKR1C1AKR1C2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281142-A1 | THIAZOLE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-12 | — | — | US | disclosed |
| EP-1921074-A1 | THIAZOLE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281142-A1 | THIAZOLE DERIVATIVE | GK, GCKR, AK2 | GRIK1 140/4885MAOA 3675/4885MAOB 3981/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.