Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | KDM4B | O94953 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27370392 | 0.79 | GABRA5 (0.46) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL20640303 | 0.78 | GABRA5 (0.44) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL9355256 | 0.77 | TSHR (0.45) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL13609550 | 0.77 | TSHR (0.61) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL3605034 | 0.76 | SMN1; SMN2 (0.46) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL27675797 | 0.76 | TSHR (0.41) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL77483 | 0.76 | SMN1; SMN2 (0.50) | TSHRHSD17B10ALDH1A1SMN1; SMN2NOS1 | |
| SCHEMBL21044247 | 0.74 | TSHR (0.48) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL4763217 | 0.74 | MEN1 (0.40) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 | |
| SCHEMBL28763146 | 0.73 | TSHR (0.41) | TSHRHSD17B10GABRA5GABRB2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281142-A1 | THIAZOLE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2009-11-12 | — | — | US | disclosed |
| EP-1921074-A1 | THIAZOLE DERIVATIVE | Astellas Pharma Inc. (JP) | 2008-05-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281142-A1 | THIAZOLE DERIVATIVE | GK, GCKR, AK2 | TSHR 1234/4885HSD17B10 827/4885GABRA5 1780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.