Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.54 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 8/20 | 0.54 |
| ▸ | DPP4 | P27487 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.50 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4255449 | 1.00 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2MCHR1DPP4 | |
| SCHEMBL4257295 | 0.87 | MAPK14 (0.57) | TAS1R3TAS1R1TAS1R2MCHR1AR | |
| SCHEMBL4257302 | 0.87 | MAPK14 (0.57) | TAS1R3TAS1R1TAS1R2MCHR1AR | |
| SCHEMBL24512806 | 0.85 | NPC1 (0.60) | TAS1R3TAS1R1TAS1R2MCHR1ADRA2A | |
| SCHEMBL4167585 | 0.85 | NPC1 (0.60) | TAS1R3TAS1R1TAS1R2MCHR1ADRA2A | |
| SCHEMBL5670790 | 0.85 | TAS1R3 (0.69) | TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL531986 | 0.85 | MCHR1 (0.64) | TAS1R3TAS1R1TAS1R2MCHR1DPP4 | |
| SCHEMBL31206154 | 0.83 | NPC1 (0.48) | MCHR1KDM1AMAOB | |
| SCHEMBL21492775 | 0.82 | BTK (0.46) | TAS1R3TAS1R1TAS1R2MCHR1CYP2C9 | |
| SCHEMBL21492774 | 0.82 | BTK (0.46) | TAS1R3TAS1R1TAS1R2MCHR1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMECUTICAL CO., LTD. (JP) | 2009-02-05 | — | — | US | disclosed |
| EP-1730122-A2 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-12-13 | — | — | EP | disclosed |
| WO-2005095357-A2 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036448-A1 | PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | GPR119, HCRTR2, MCHR1 | TAS1R3 1598/4885TAS1R1 963/4885TAS1R2 968/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.