SCHEMBL4255601

SCHEMBL4255601

CC(N)c1cn(S(=O)(=O)c2cccnc2)c(-c2ccccc2)c1F

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.35
CYP3A5 P20815 1/20 0.35
KDM4E B2RXH2 1/20 0.35
SLC1A3 P43003 1/20 0.35
SLC1A2 P43004 1/20 0.35
SLC1A1 P43005 1/20 0.35
NAPRT Q6XQN6 1/20 0.34
PTGS2 P35354 4/20 0.33
HTR6 P50406 3/20 0.33
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CHRNB2 P17787 1/20 0.33
CHRNB4 P30926 1/20 0.33
CHRNA3 P32297 1/20 0.33
CHRNA4 P43681 1/20 0.33
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28801289 0.84 FEN1 (0.35) KDM4ESLC1A3SLC1A2SLC1A1NAPRT
SCHEMBL1278495 0.78 SMN1; SMN2 (0.40) CYP3A4CYP3A5KDM4ENAPRTHTR6
SCHEMBL194316 0.77 HTR6 (0.39) KDM4EHTR6CHRNB2CHRNB4CHRNA3
SCHEMBL1278632 0.77 KMT2A (0.49) KDM4ECA12CA1CA2CA9
Hydrochloric Acid SCHEMBL1278272 0.76 HTR6 (0.39) KDM4EHTR6CHRNB2CHRNB4CHRNA3
SCHEMBL22769478 0.72 KDM4E (0.39) CYP3A4CYP3A5KDM4ENAPRTPTGS2
SCHEMBL1156646 0.71 KDM4E (0.41) CYP3A4KDM4ENAPRTPTGS2HTR6
SCHEMBL17748242 0.70 CHRNB2 (0.38) CYP3A4CYP3A5KDM4ENAPRTPTGS2
Methylamine SCHEMBL28637857 0.69 CYP2A6 (0.40) KDM4ENAPRTPTGS2HTR6CA12
SCHEMBL1156179 0.69 HTR6 (0.42) HTR6CYP11B2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113149883-B Process for preparing pyrrole compounds 武田药品工业株式会社 2024-04-02 CN disclosed
US-7498337-B2 Acid secretion inhibitor TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-03-03 US disclosed