Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | VSIR | Q9H7M9 | 5/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
| ▸ | NSD2 | O96028 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.30 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.30 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082823 | 0.93 | AKT1 (0.39) | AKT1S1PR1VSIRHDAC1CD274 | |
| SCHEMBL4074510 | 0.90 | AKT1 (0.36) | AKT1VSIRHDAC1MAPTMAPK1 | |
| SCHEMBL4081718 | 0.88 | AKT1 (0.35) | AKT1S1PR1VSIRHDAC1MAPT | |
| SCHEMBL4080115 | 0.88 | AKT1 (0.35) | AKT1S1PR1VSIRHDAC1OPRL1 | |
| SCHEMBL4071465 | 0.79 | CSNK2A1 (0.40) | AKT1VSIRHDAC1CD274OPRL1 | |
| SCHEMBL13633146 | 0.79 | SCN8A (0.35) | AKT1S1PR1VSIRHDAC1CD274 | |
| Hydrochloric Acid SCHEMBL4490670 | 0.78 | SCN8A (0.35) | AKT1S1PR1VSIRHDAC1CD274 | |
| SCHEMBL13137130 | 0.77 | HTT (0.39) | AKT1S1PR1VSIRHDAC1MAPT | |
| Hydrochloric Acid SCHEMBL3050316 | 0.76 | HTT (0.39) | AKT1S1PR1VSIRHDAC1MAPT | |
| SCHEMBL4081754 | 0.73 | KDM4E (0.41) | HDAC1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |