Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | VSIR | Q9H7M9 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13633146 | 0.91 | SCN8A (0.35) | AKT1HDAC1PDCD1LG2CD274S1PR1 | |
| Hydrochloric Acid SCHEMBL4490670 | 0.90 | SCN8A (0.35) | AKT1HDAC1PDCD1LG2CD274S1PR1 | |
| SCHEMBL4256175 | 0.88 | AKT1 (0.38) | AKT1HDAC1CD274S1PR1VSIR | |
| SCHEMBL4080115 | 0.85 | AKT1 (0.35) | AKT1HDAC1S1PR1VSIRMAPK14 | |
| SCHEMBL4082823 | 0.83 | AKT1 (0.39) | AKT1HDAC1CD274S1PR1VSIR | |
| SCHEMBL4083648 | 0.80 | HDAC1 (0.33) | AKT1HDAC1VSIR | |
| SCHEMBL4074510 | 0.79 | AKT1 (0.36) | AKT1HDAC1CD274VSIRMAPT | |
| SCHEMBL4071465 | 0.78 | CSNK2A1 (0.40) | AKT1HDAC1PDCD1LG2CD274VSIR | |
| SCHEMBL30312213 | 0.71 | DHODH (0.41) | — | |
| SCHEMBL13633142 | 0.70 | OPRM1 (0.45) | HDAC1S1PR1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |