SCHEMBL425625

SCHEMBL425625

Cc1cccc(C=NNc2cc(N(C)C)nc(OCC(C)(C)O)n2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 13/20 0.47
APAF1 O14727 4/20 0.47
SENP8 Q96LD8 3/20 0.47
SENP7 Q9BQF6 3/20 0.47
SENP6 Q9GZR1 3/20 0.47
NSD2 O96028 3/20 0.47
SAE1 Q9UBE0 3/20 0.47
UBA2 Q9UBT2 3/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CASP3 P42574 1/20 0.47
KDM4E B2RXH2 7/20 0.44
LMNA P02545 7/20 0.44
SMN1; SMN2 Q16637 4/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
NPC1 O15118 4/20 0.44
RAB9A P51151 3/20 0.44
NPSR1 Q6W5P4 3/20 0.44
HTT P42858 3/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL425624 1.00 MAPT (0.47) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL424843 0.90 PIKFYVE (0.43) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL424842 0.90 PIKFYVE (0.43) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL13759206 0.90 MAPT (0.43) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL14530773 0.89 MAPT (0.47) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL425902 0.88 PIKFYVE (0.42) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL425901 0.88 PIKFYVE (0.42) MAPTAPAF1SENP8SENP7SENP6
SCHEMBL1603059 0.86 MAPT (0.46) MAPTKDM4ELMNASMN1; SMN2MEN1
SCHEMBL1603061 0.86 MAPT (0.46) MAPTKDM4ELMNASMN1; SMN2MEN1
SCHEMBL14530780 0.86 PIKFYVE (0.40) MAPTAPAF1SENP8SENP7SENP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7919487-B2 Heteroaryl compounds SYNTA PHARMACEUTICALS CORPORATION (US) 2011-04-05 US claimed
US-20060122156-A1 Heteroaryl compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-06-08 US claimed
US-20150174132-A1 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS SYNTA PHARMACEUTICALS CORP (US) 2015-06-25 US disclosed
US-20120021434-A1 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS SYNTA PHARMACEUTICALS CORP. (US) 2012-01-26 US disclosed
US-20110098267-A1 TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS SYNTA PHARMACEUTICALS CORPORATION (US) 2011-04-28 US disclosed
US-7919487-B2 Heteroaryl compounds SYNTA PHARMACEUTICALS CORPORATION (US) 2011-04-05 US disclosed
US-20090163708-A1 PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2009-06-25 US disclosed
US-20070032493-A1 Method for treating B cell regulated autoimmune disorders SYNTA PHARMACEUTICALS CORP. (US) 2007-02-08 US disclosed
US-20060122156-A1 Heteroaryl compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-06-08 US disclosed
WO-2006053109-A1 HETEROARYL COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110098267-A1 TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS IL17A, IL23R, IL15 MAPT 238/4885APAF1 2137/4885SENP8 1478/4885
US-20150174132-A1 METHOD FOR TREATING B CELL REGULATED AUTOIMMUNE DISORDERS REL, NFATC1, BCL6 MAPT 4316/4885APAF1 1225/4885SENP8 2076/4885
US-20060122156-A1 Heteroaryl compounds IL2, CCL11, IL4 MAPT 2813/4885APAF1 971/4885SENP8 3172/4885
US-20090163708-A1 PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS IL17A, IL23R, IL2 MAPT 2815/4885APAF1 728/4885SENP8 723/4885
US-20070032493-A1 Method for treating B cell regulated autoimmune disorders REL, NFATC1, BCL6 MAPT 4316/4885APAF1 1225/4885SENP8 2076/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.