SCHEMBL4256569

SCHEMBL4256569

Nc1ccc2oc(C(=O)O)cc(=O)c2c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.69
CSNK2A1 P68400 4/20 0.65
CSNK2A2 P19784 3/20 0.65
CSNK2B P67870 3/20 0.65
CSNK2A3 Q8NEV1 3/20 0.65
KDM4E B2RXH2 3/20 0.65
USP2 O75604 1/20 0.65
PTGS1 P23219 1/20 0.65
AKR1B1 P15121 1/20 0.57
EGFR P00533 1/20 0.57
SRC P12931 1/20 0.57
MAPT P10636 2/20 0.55
NPC1 O15118 2/20 0.55
RAB9A P51151 2/20 0.55
SMN1; SMN2 Q16637 2/20 0.55
GFER P55789 1/20 0.55
PIM1 P11309 3/20 0.53
GPR35 Q9HC97 1/20 0.49
GLA P06280 1/20 0.49
HPGD P15428 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4248840 0.86 AKR1B1 (0.71) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL2976354 0.83 AKR1B1 (0.76) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL18144902 0.83 ALDH1A1 (0.69) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL2769879 0.81 ALDH1A1 (0.67) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL379054 0.81 ALDH1A1 (0.67) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL2318176 0.81 ALDH1A1 (0.67) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL1504213 0.81 ALDH1A1 (1.00) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL4246461 0.81 KDM4E (0.59) ALDH1A1KDM4EAKR1B1EGFRSRC
SCHEMBL15832597 0.80 ALDH1A1 (0.65) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3
SCHEMBL18686191 0.80 ALDH1A1 (0.65) ALDH1A1CSNK2A1CSNK2A2CSNK2BCSNK2A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101497571-B Process for producing chromone compound SUMITOMO CO LTD 2012-07-04 CN disclosed
CN-1911896-B Process for producing benzopyrone compound SUMITOMO CHEMICAL CO 2010-09-15 CN disclosed
EP-2105431-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
EP-2105432-A1 Process for Producing Chromone Compound Sumitomo Chemical Company, Limited (JP) 2009-09-30 EP disclosed
CN-101497571-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2009-08-05 CN disclosed
CN-100509751-C Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2009-07-08 CN disclosed
EP-1867626-A2 Process for producing chromone compound Sumitomo Chemical Company, Limited (JP) 2007-12-19 EP disclosed
CN-1911896-A Process for producing chromone compound SUMITOMO CHEMICAL CO (JP) 2007-02-14 CN disclosed
US-20060217565-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-09-28 US disclosed
US-7094914-B2 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-08-22 US disclosed
CN-1649824-A Process for producing benzopyranone compound SUMITOMO CHEMICAL CO (JP) 2005-08-03 CN disclosed
US-20050085664-A1 Process for producing chromone compound SUMITOMO CHEMICAL COMPANY, LMITED (JP) 2005-04-21 US disclosed
EP-1479667-A1 PROCESS FOR PRODUCING CHROMONE COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050085664-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL ALDH1A1 3157/4885CSNK2A1 513/4885CSNK2A2 405/4885
US-20060217565-A1 Process for producing chromone compound ENY2, CDY1; CDY1B, CDYL ALDH1A1 3157/4885CSNK2A1 513/4885CSNK2A2 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.