Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | APAF1 | O14727 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | XBP1 | P17861 | 1/20 | 0.52 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | GALK1 | P51570 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30862544 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL31485753 | 1.00 | ALDH1A1 (0.52) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL6754212 | 0.97 | ALDH1A1 (0.55) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL28184105 | 0.93 | ALDH1A1 (0.60) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL608537 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL29414275 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL29352295 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL30332559 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL192419 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD | |
| SCHEMBL29414264 | 0.93 | ALDH1A1 (0.58) | ALDH1A1HSD17B10BCL2L1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765756-B1 | OLIGOMERIC DERIVATIVES OF SPIROBIFLUORENE, THEIR PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2016-12-28 | — | — | EP | claimed |
| US-8614357-B2 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2013-12-24 | — | — | US | claimed |
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2009-09-17 | — | — | US | claimed |
| EP-1765756-B1 | OLIGOMERIC DERIVATIVES OF SPIROBIFLUORENE, THEIR PREPARATION AND USE | MERCK PATENT GMBH (DE) | 2016-12-28 | — | — | EP | disclosed |
| US-8614357-B2 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2013-12-24 | — | — | US | disclosed |
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | MERCK PATENT GMBH (DE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090234164-A1 | Oligomeric derivatives of spirobifluorene, their preparation and use | NR3C2, NR0B2, NR0B1 | ALDH1A1 2385/4885HSD17B10 1177/4885BCL2L1 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.