Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 1.00 |
| ▸ | BCHE | P06276 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | FAAH | O00519 | 1/20 | 0.98 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.98 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.98 |
| ▸ | PDE5A | O76074 | 1/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | APP | P05067 | 1/20 | 0.98 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.98 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.98 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.98 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.98 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.98 |
| ▸ | DRD4 | P21917 | 1/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | MAOB | P27338 | 1/20 | 0.98 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL3091472 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL29424585 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL5060933 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1815 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1559622 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1123745 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4312618 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4315806 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL8265876 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL3851203 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2098232-B1 | PERCUTANEOUS ABSORPTION PREPARATION | NITTO DENKO CORP (JP) | 2013-06-05 | — | — | EP | disclosed |
| EP-2098232-A1 | PERCUTANEOUS ABSORPTION PREPARATION | NITTO DENKO CORPORATION (JP) | 2009-09-09 | — | — | EP | disclosed |
| US-20080131491-A1 | Percutaneously absorbable preparation | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-06-05 | — | — | US | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0579263-A1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1994-01-19 | — | — | EP | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |