Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 5/20 | 1.00 |
| ▸ | BCHE | P06276 | 5/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | FAAH | O00519 | 1/20 | 0.96 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.96 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.96 |
| ▸ | PDE5A | O76074 | 1/20 | 0.96 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.96 |
| ▸ | APP | P05067 | 1/20 | 0.96 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.96 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.96 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.96 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.96 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.96 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.96 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.96 |
| ▸ | DRD4 | P21917 | 1/20 | 0.96 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.96 |
| ▸ | MAOB | P27338 | 1/20 | 0.96 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.96 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL4315806 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4312618 | 1.00 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL29424585 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL356844 | 0.99 | BCHE (0.98) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL3091472 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1815 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL1559622 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL5060933 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4979379 | 0.99 | BCHE (0.98) | BCHEACHEKDM4EFAAHABCC4 | |
| Donepezil SCHEMBL4256889 | 0.99 | BCHE (1.00) | BCHEACHEKDM4EFAAHABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021118004-A1 | COMPLEX FORMULATION COMPRISING DONEPEZIL AND MEMANTINE | 주식회사 종근당 | 2021-06-17 | — | — | WO | claimed |
| WO-2015109377-A1 | PROCESS FOR PREPARING DONEPEZIL HYDROCHLORIDE FORMS I AND III; AND AN INTERMEDIATE COMPOUND THEREOF | Cristália Produtos Químicos Farmacêuticos Ltda. (BR) | 2015-07-30 | — | — | WO | claimed |
| US-20120283291-A1 | SOLID PHARMACEUTICAL COMPOSITION COMPRISING DONEPEZIL HYDROCHLORIDE | KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO (SI) | 2012-11-08 | — | — | US | claimed |
| EP-2283811-A1 | Solid pharmaceutical composition comprising donepezil hydrochloride | Krka Tovarna Zdravil, D.D., Novo Mesto (SI) | 2011-02-16 | — | — | EP | claimed |
| US-20100317694-A1 | Solid pharmaceutical composition comprising donepezil hydrochloride | KRKA, TOVARNA ZDRAVIL, D.D. , NOVO MESTO (SI) | 2010-12-16 | — | — | US | claimed |
| US-20100055171-A1 | Pharmaceutical Formulation Comprising Donepezil | PLIVA HRVATSKA D.O.O. (HR) | 2010-03-04 | — | — | US | claimed |
| US-7560560-B2 | Crystalline forms of donepezil hydrochloride | HETERO DRUGS LIMITED (US) | 2009-07-14 | — | — | US | claimed |
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA HRVATSKA D.O.O | 2009-05-28 | — | — | US | claimed |
| US-20090130205-A9 | Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride | KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO (SI) | 2009-05-21 | — | — | US | claimed |
| EP-2043618-A1 | PHARMACEUTICAL FORMULATION COMPRISING DONEPEZIL | PLIVA HRVATSKA d.o.o. (HR) | 2009-04-08 | — | — | EP | claimed |
| US-20080063705-A1 | Solid Pharmaceutical Composition Comprising Donepezil Hydrochloride | KRKA, TOVARNA ZDRAVIL D.D., NOVO MESTO (SI) | 2008-03-13 | — | — | US | claimed |
| WO-2008012495-A1 | PHARMACEUTICAL FORMULATION COMPRISING DONEPEZIL | PLIVA HRVATSKA D.O.O. (HR) | 2008-01-31 | — | — | WO | claimed |
| EP-1858848-A1 | PROCESS FOR MAKING CRYSTALLINE DONEPEZIL HYDROCHLORIDE MONOHYDRATE | Synthon B.V. (NL) | 2007-11-28 | — | — | EP | claimed |
| EP-1811957-A1 | SOLID PHARMACEUTICAL COMPOSITION COMPRISING DONEPEZIL HYDROCHLORIDE | KRKA, tovarna zdravil, d.d., Novo mesto (SI) | 2007-08-01 | — | — | EP | claimed |
| WO-2007015052-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | PLIVA ISTRAZIVANJE I RAZVOJ D.O.O. (HR) | 2007-02-08 | — | — | WO | claimed |
| US-20060258705-A1 | Process for making crystalline donepezil hydrochloride monohydrate | SYNTHON BV (NL) | 2006-11-16 | — | — | US | claimed |
| WO-2006097341-A1 | PROCESS FOR MAKING CRYSTALLINE DONEPEZIL HYDROCHLORIDE MONOHYDRATE | SYNTHON B.V. (NL) | 2006-09-21 | — | — | WO | claimed |
| WO-2006045512-A1 | SOLID PHARMACEUTICAL COMPOSITION COMPRISING DONEPEZIL HYDROCHLORIDE | KRKA, TOVARNA ZDRAVIL (SI) | 2006-05-04 | — | — | WO | claimed |
| US-20050215591-A1 | Novel crystalline forms of donepezil hydrochloride | HETERO DRUGS LIMITED (IN) | 2005-09-29 | — | — | US | claimed |
| WO-2004092137-A1 | NOVEL CRYSTALLINE FORMS OF DONEPEZIL HYDROCHLORIDE | HETERO DRUGS LIMITED (IN) | 2004-10-28 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137811-A1 | PROCESS FOR THE PREPARATION OF DONEPEZIL AND INTERMEDIATE COMPOUNDS THEREOF AS WELL AS HYDRATES OF DONEPEZIL | ACHE, BCHE, WIZ | ACHE 1/4885BCHE 2/4885KDM4E 727/4885 |
| US-20050215591-A1 | Novel crystalline forms of donepezil hydrochloride | ACHE, BCHE, MAPT | ACHE 1/4885BCHE 2/4885KDM4E 437/4885 |
| US-20060258705-A1 | Process for making crystalline donepezil hydrochloride monohydrate | CHRM2, C5, C9 | ACHE 29/4885BCHE 4/4885KDM4E 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.